We are dedicated to offering advanced mental health treatments that bring real hope to those who have struggled with traditional options.
One of the most groundbreaking therapies we provide is Spravato®(esketamine), a cutting-edge medication designed to help individuals suffering from treatment-resistant depression.
By incorporating Spravato into our comprehensive care plans, we provide our patients with a new avenue towards recovery and a better quality of life.
Spravato (esketamine) nasal spray is an FDA-approved treatment specifically developed for adults with treatment-resistant depression. Unlike standard antidepressants that may take weeks to show effects, Spravato offers rapid relief by acting on NMDA receptors in the brain, leading to significant improvements in depressive symptoms within a much shorter time frame.
Spravato (esketamine) nasal spray is an FDA-approved treatment specifically developed for adults with treatment-resistant depression. Unlike standard antidepressants that may take weeks to show effects, Spravato offers rapid relief by acting on NMDA receptors in the brain, leading to significant improvements in depressive symptoms within a much shorter time frame.
The active ingredient in Spravato, esketamine, targets NMDA receptors in the brain, which are critical to mood regulation and cognitive function. By modulating these receptors, Spravato increases levels of glutamate, a neurotransmitter essential for brain communication and synaptic plasticity. This process, known as synaptogenesis, helps alleviate depressive symptoms and improve overall mood.
Spravato nasal spray is an excellent option for adults who have tried multiple antidepressant treatments without success. Some specific conditions where Spravato can be life-changing include:
If you’ve tried at least two different antidepressant medications and haven’t experienced significant improvement, Spravato may offer a solution.
Major Depressive Disorder (MDD)
If you or a loved one is experiencing suicidal ideation linked to severe depression, Spravato could offer fast-acting relief and potentially save lives.
Initial Consultation
Your journey with Spravato begins with a thorough consultation. During this session, our medical team will review your psychiatric history, current medications, and previous treatments to determine if Spravato is the right choice for you.
Treatment Sessions
Spravato is self-administered by the patient in our comfortable, private treatment rooms. The nasal spray is used under close supervision by our clinical staff.
Monitoring and Follow-Up
Following each session, patients remain at our center for at least two hours for observation. This allows us to monitor for any potential side effects, such as increased blood pressure, dissociation, or sedation. Regular follow-up appointments help us assess treatment progress and make any necessary adjustments.
While each person’s experience with Spravato may differ, our team at Piedmont Neuroscience Center has seen firsthand the powerful impact it can have on those living with depression.
The typical course of Spravato treatment starts with two sessions per week for the first month, followed by once-weekly sessions for the next month. After this initial period, the frequency of sessions is gradually reduced, depending on your individual progress and needs.
It’s a nasal spray containing esketamine that rapidly targets brain receptors involved in mood regulation.
Adults with treatment-resistant depression who haven’t responded to multiple antidepressants.
It acts faster and through different brain pathways than typical SSRIs.
Self-administered in the office under supervision, with a two-hour observation period afterward.
Common side effects include dizziness, dissociation, and nausea.
Usually twice weekly for the first 4 weeks, then once weekly or biweekly.
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